US Biopharmaceuticals: Reminder: Expert call on Agios’ AQVESME launch in thalassemia; TODAY at 10am ET

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US Biopharmaceuticals: Reminder: Expert call on Agios’ AQVESME launch in thalassemia; TODAY at 10am ET

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US Biopharmaceuticals

Reminder: Expert call on Agios’ AQVESME

launch in thalassemia; TODAY at 10am ET

Invitation

Topic 08 June 2026

With the AQVESME launch now underway in thalassemia, we hope to provide an updated Equity

perspective on real-world uptake, early physician and patient experience, and the United States

practical considerations shaping intended use. We are hosting a conference call with Dr. Biopharmaceuticals

Sujit Sheth, MD, Chief of Pediatric Hematology/Oncology at Weill Cornell Medicine and

Related ResearchNewYork-Presbyterian Hospital, who currently manages ~250 thalassemia patients.

We will discuss Dr. Sheth’s hands-on AQVESME experience (as an investigator on the Agios Pharmaceuticals: Tebapivat LR-MDS miss

ENERGIZE studies and in the commercial setting), including patient selection, response narrows AGIO focus to thal launch and SCD

expectations, monitoring logistics, and how REMS requirements are affecting treatment readouts

initiation and follow-up in the U.S. The discussion will also touch on how labeling and Agios Pharmaceuticals: EU thalassemia

access considerations may differ outside the U.S., including markets without a approved without REMS; further validates

launch trajectorymandatory REMS program, and what that could imply for labeling/adoption over time. Agios Pharmaceuticals: Solid demand signals

More broadly, we will discuss how AQVESME may fit into the evolving thalassemia in thalassemia, SCD a larger debate with

treatment landscape alongside supportive care, luspatercept, and potentially curative sNDA filing in 2Q26e

approaches including gene therapy and gene editing. Agios Pharmaceuticals: Etavopivat topline data