Clinical Trial Pipeline Tracker

Research evidence excerpt

Clinical Trial Pipeline Tracker

UpdateM

Upsized/Downsized

Exhibit 9: Trials with increased estimated patient recruitment

Primary Previous

Company Drug Stage Event/Study title Status Est. Size Identifier

Completion Est. Size

A Study to Evaluate the Safety, Tolerability, and PK of an

Bristol-Myers Squibb KarXT Phase1 Jun-27 Recruiting 116 48 NCT07061288

Injectable Form of KarXT

Sofetabart

A Three-Part Phase 3 Study of Sofetabart Mipitecan in

Mipitecan|Paclitaxel|Topotecan|Gemcit

Eli Lilly Phase3 Participants With Platinum-Resistant (Part A) and Platinum- Nov-28 Recruiting 1630 1080 NCT07213804

abine|Pegylated liposomal doxorubicin

Sensitive (Parts B and C) Ovarian Cancer

(PLD)|MIRV|Bevacizumab|Carboplatin

Study of GS-4321 in Healthy Participants and Participants

Gilead GS-4321|GS-4321 Phase1|Phase2 Jan-30 Recruiting 200 107 NCT07096193

With Chronic Hepatitis Delta Virus

Pharmacokinetics, Safety and Tolerability of Crinecerfont in

Active, not

Neurocrine Crinecerfont Phase2 Participants With Congenital Adrenal Hyperplasia Who Are Sep-29 7 6 NCT07187375

recruiting

Less Than 2 Years Old

Multivalent Pneumococcal Vaccine -

Formulation 1|Multivalent

Pneumococcal Vaccine - Formulation

2|20-valent pneumococcal conjugate

A Study to Learn About the Safety and Immune Response of

Pfizer vaccine (20vPnC)|Licensed Phase1|Phase2 May-26 Completed 1363 558 NCT06182124

a New Pneumococcal Vaccine in Adults

pneumococcal comparator

vaccine|Multivalent Pneumococcal

Vaccine - Formulation 3|Multivalent

Pneumococcal Vaccine - Formulation 4

Source: Company data, Clinicaltrials.gov, Morgan Stanley Research

Exhibit 10: Trials with decreased estimated patient recruitment

Primary Previous Est.

Completion Size

A Phase 1 Study to Assess the Effect of ABBV-722 on Ethinyl