Introducing The Century Project | Vol. I

研报英文原文证据摘录

Introducing The Century Project | Vol. I

ividuals, GLP-1 RAs and

GLP-1/GIP dual agonists can help reduce the risk of cardiovascular

issues, Alzheimer’s, Parkinson’s and potentially obesity-related

cancers. For these patients, these two types of drugs can be

rightfully considered longevity drugs. There is no research on

the potential benefits of GLP-1 RAs and GLP-1/GIP dual agonists

for healthy people—the target population of our research.

• Urolithin A. There is not enough research involving Urolithin

A supplementation to conclude that Urolithin A is an anti-aging

supplement—helping to prevent or delay the onset of the four main

chronic diseases. Most of the positive results from studies on Urolithin

A supplementation have involved older people and/or people with

low physical activity levels. These data cannot be extrapolated to a

younger and healthier population. However, there are autophagy and

mitophagy benefits associated with Urolithin A supplementation,

1 Autophagy: —auto-phagos, or eating yourself in ancient Greek—is a self-degradative process at the cellular level that plays a key role in balancing sources of energy at critical times during development and in

response to nutrient stress. Autophagy also plays a housekeeping role in removing misfolded or aggregated proteins, clearing damaged organelles, as well as eliminating intracellular pathogens, allowing

this debris to be reused in cell growth. Autophagy is generally thought of as a conserved survival mechanism. In addition to elimination of intracellular aggregates and damaged organelles, autophagy

promotes cellular senescence and cell surface antigen presentation, protects against genome instability and prevents necrosis, giving it a key role in preventing diseases such as cancer, neurodegeneration,