Gilead Sciences Inc.: Takeaways from our KOL call on GILD’s Yeztugo launch in HIV PrEP

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Gilead Sciences Inc.: Takeaways from our KOL call on GILD’s Yeztugo launch in HIV PrEP

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Gilead Sciences Inc.

Takeaways from our KOL call on GILD’s

Yeztugo launch in HIV PrEP

Maintain Rating: BUY | PO: 162.00 USD | Price: 129.90 USD

Yeztugo approval growing the HIV PrEP market 18 May 2026

We hosted Dr. Kassem Bourgi, infectious disease specialist, to discuss the evolving HIV Equity

PrEP treatment paradigm with a specific focus on early real-world experience with

Tazeen Ahmad

GILD’s Yeztugo. Our KOL highlighted an overall positive view on Yeztugo, noting it as a Research Analyst

highly differentiated therapy vs current options given its convenient dosing regimen, BofAS +1 646 855 4236

reduced patient and physician burden and favorable tolerability. Additionally, he cited tazeen.ahmad@bofa.com

benefits from existing infrastructure from Apretude. Early uptake has been driven Daniel Giraldo

primarily by patient-driven switches, particularly from Apretude, rather than PrEP-naïve ResearchBofAS Analyst

starts. Our KOL believes Yeztugo could expand the PrEP market through broader disease daniel.giraldoperez@bofa.com

and therapy awareness. He estimates that in about 12-18 months roughly half of his Jeremiah Lorentz

PrEP-eligible patients could be on Yeztugo, which we note is in-line with recent GILD ResearchBofAS Analyst

commentary on Yeztugo overtime becoming the leading PrEP therapy (see our 5/13 jeremiah.lorentz@bofa.com

Vegas dinner takeaways note). We maintain our Buy with $162 PO. Wesley Yon

Research Analyst

Strong initial persistence, likely to normalize BofASwesley.yon@bofa.com

He noted early Yeztugo retreatment rates are favorable with nearly all eligible patients

having been retreated or scheduled for retreatment with only one patient dropping off