Sleep KOL Call: Update on CPAP/HGNS; Thoughts on GLPs

Research evidence excerpt

Sleep KOL Call: Update on CPAP/HGNS; Thoughts on GLPs

Medical Supplies & Devices

Equity Research

June 22, 2026

Jefferies Financial Group Inc., its affiliates or subsidiaries beneficially owned 1% or more of the common equity of Inspire Medical Systems as of last month's

end (or the prior month’s end if this report is dated later than 10 days after the most recent month end).

Explanation of Jefferies Ratings

Buy - Describes securities that we expect to provide a total return (price appreciation plus yield) of 15% or more within a 12-month period.

Hold - Describes securities that we expect to provide a total return (price appreciation plus yield) of plus 15% or minus 10% within a 12-month period.

Underperform - Describes securities that we expect to provide a total return (price appreciation plus yield) of minus 10% or less within a 12-month period.

The expected total return (price appreciation plus yield) for Buy rated securities with an average security price consistently below $10 is 20% or more within a 12-

month period as these companies are typically more volatile than the overall stock market. For Hold rated securities with an average security price consistently

below $10, the expected total return (price appreciation plus yield) is plus or minus 20% within a 12-month period. For Underperform rated securities with an

average security price consistently below $10, the expected total return (price appreciation plus yield) is minus 20% or less within a 12-month period.

NR - The investment rating and price target have been temporarily suspended. Such suspensions are in compliance with applicable regulations and/or Jefferies

policies.

CS - Coverage Suspended. Jefferies has suspended coverage of this company.

NC - Not covered. Jefferies does not cover this company.