NTRA Announces Enhanced Panorama Available at 8 Weeks of Gestation

Research evidence excerpt

NTRA Announces Enhanced Panorama Available at 8 Weeks of Gestation

FLASH NOTE

May 26, 2026

Subbu Nambi, Ph.D. subbu.nambi@guggenheimpartners.com NTRA Announces Enhanced Panorama Available at

617 874 7383 8 Weeks of Gestation

Ricki Levitus

ricki.levitus@guggenheimpartners.com

212 823 6556 Key Message: NTRA announced that the company will launch an enhanced Panorama

test, powered by "novel SNP-informed deep sequencing technology". This allows Thomas VonDerVellen

thomas.vondervellen@guggenheimpartners.com Panorama to produce accurate results even at lower fetal fractions, lowering the no-call

617 859 4657 rate to 0.5% and enabling Panorama at 8 weeks of gestation. Our prior diligence with

OBGYNs has suggested that earlier NIPT results would be clinically meaningful in this

setting where time is increasingly valuable.

NTRA Internal Study Data

Natera, Inc. The enhanced Panorama assay is backed by blinded clinical validation data that was Sector: Diagnostics & Life Sciences Tools • included in the press release. In this study of 3,323 pregnant patients (low and high risk

Company Update pregnancies), 242 samples were deemed to have a low fetal fraction that previously would not have gotten a Panorama result. As part of the study design, all pregnancies included

Share Price $203.19 in the study had diagnostic genetic testing performed to confirm Panorama results.

At low fetal fractions, Panorama performance was 100% sensitivity for trisomy 21 (prior •

Market Data Panorama performance data was 99% in all pregnancies), 93.3% sensitivity for trisomy

52-Week Range $131.81 - $256.36 18 (prior Panorama performance data was 94% sensitivity in all pregnancies) and 100%

sensitivity for trisomy 13 (prior Panorama performance data was >99% sensitivity in all Shares Out (M) 143.2