The maximum quartet distance between phylogenetic trees

Abstract

The quartet distance counts the four-leaf subsets on which two binary phylogenetic trees display different topologies. We prove that its maximum over trees on $n$ leaves is $(2/3+o(1))\binom{n}{4}$, resolving a conjecture of Bandelt and Dress from 1986 and calibrating the scale of a fundamental metric for comparing phylogenetic trees. The proof reduces arbitrary pairs of trees to caterpillars by means of a common-root planarization and an identity on five-leaf trees.